Prof. Dr. Akiko Iwasaki, Yale School of Medicine, in collaboration with the PolyBio Research Foundation.
Prof. Iwasaki and her team examine blood samples and cerebrospinal fluid (CSF) from ME/CFS patients for immune profiles and antibodies against various pathogens.
In a groundbreaking new study, co-funded by our Johadamis Award, renowned scientists led by Prof. Akiko Iwasaki (Yale University) and Dr. Amy Proal (PolyBio Research Foundation) analyzed immune activity in the cerebrospinal fluid of people with ME/CFS.
For the first time, two different immune subtypes were identified within the patient group—even though the clinical symptoms were similar. These subtypes differed in particular in terms of inflammation patterns in the central nervous system and evidence of previous viral infections, such as cytomegalovirus (CMV) or SARS-CoV-2.
The results support the hypothesis that ME/CFS is not a single disease, but rather a heterogeneous syndrome with different biological causes. This is an important step toward more precise diagnostic procedures and individually tailored therapeutic approaches.
You can read the entire study here: https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf087/8133211?login=false
